1. What is the HOMA-IR Equation?

The HOMA-IR (Homeostatic Model Assessment for Insulin Resistance) is a method used to quantify insulin resistance and beta-cell function from fasting glucose and insulin measurements. It provides a simple assessment of insulin sensitivity using mg/dL units.

2. How Does the Calculator Work?

The calculator uses the HOMA-IR equation:

Where:

• Fasting Insulin — Measured in μU/mL
• Fasting Glucose — Measured in mg/dL

Explanation: The equation calculates insulin resistance by assessing the relationship between fasting insulin and glucose levels, with higher values indicating greater insulin resistance.

3. Importance of HOMA-IR Calculation

Details: HOMA-IR is widely used in clinical research and practice to identify insulin resistance, which is associated with metabolic syndrome, type 2 diabetes, and cardiovascular disease risk.

4. Using the Calculator

Tips: Enter fasting insulin in μU/mL and fasting glucose in mg/dL. Both values must be valid (greater than 0). Morning fasting samples provide the most accurate results.

5. Frequently Asked Questions (FAQ)

Q1: What is a normal HOMA-IR value?
A: Typically, values below 2.0 are considered normal, though this may vary by population and laboratory reference ranges.

Q2: How does HOMA-IR relate to diabetes risk?
A: Higher HOMA-IR values indicate greater insulin resistance, which is a major risk factor for developing type 2 diabetes.

Q3: When should insulin and glucose be measured?
A: Morning fasting samples are ideal, collected after an overnight fast of 8-12 hours for accurate assessment.

Q4: Are there limitations to HOMA-IR?
A: HOMA-IR provides an estimate rather than a direct measurement and may be less accurate in certain conditions like liver disease or extreme obesity.

Q5: Can HOMA-IR be used for diagnosis?
A: While useful for screening and research, HOMA-IR should be interpreted alongside clinical assessment and other diagnostic tests.