1. What is HOMA-IR?

HOMA-IR (Homeostatic Model Assessment for Insulin Resistance) is a method used to quantify insulin resistance and beta-cell function. It provides an estimate of insulin resistance based on fasting glucose and insulin levels.

2. How Does the Calculator Work?

The calculator uses the HOMA-IR formula:

Where:

• Fasting Insulin — Measured in micro international units per liter (μU/L)
• Fasting Glucose — Measured in millimoles per liter (mmol/L)
• 22.5 — Normalization constant

Explanation: The formula calculates insulin resistance by assessing the relationship between fasting insulin and glucose levels.

3. Importance of HOMA-IR Calculation

Details: HOMA-IR is crucial for assessing insulin resistance, which is associated with type 2 diabetes, metabolic syndrome, and cardiovascular diseases. It helps in early detection and monitoring of insulin resistance.

4. Using the Calculator

Tips: Enter fasting insulin in μU/L and fasting glucose in mmol/L. Both values must be greater than zero for accurate calculation.

5. Frequently Asked Questions (FAQ)

Q1: What is a normal HOMA-IR value?
A: Typically, HOMA-IR values below 2.0 are considered normal, while values above 2.0 may indicate insulin resistance. However, reference ranges may vary.

Q2: Why use mmol/L for glucose?
A: The HOMA-IR formula was originally developed using mmol/L units. Using other units requires conversion for accurate results.

Q3: When should I measure fasting insulin and glucose?
A: Measurements should be taken after an overnight fast (8-12 hours) for accurate results.

Q4: Are there limitations to HOMA-IR?
A: Yes, HOMA-IR may be less accurate in certain populations, such as those with type 1 diabetes or severe insulin resistance.

Q5: Can HOMA-IR be used for diagnosis?
A: HOMA-IR is a screening tool and should be used in conjunction with other clinical assessments for diagnosis.