HOMA IR Calculator

HOMA-IR Formula:

\[ HOMA-IR = \frac{Fasting\ Insulin \times Fasting\ Glucose}{22.5} \]

HOMA-IR Score:

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1. What is the HOMA-IR Calculator?

The HOMA-IR (Homeostatic Model Assessment for Insulin Resistance) calculator estimates insulin resistance using fasting insulin and glucose levels. It provides a simple method to assess insulin sensitivity and identify potential metabolic disorders.

2. How Does the Calculator Work?

The calculator uses the HOMA-IR formula:

\[ HOMA-IR = \frac{Fasting\ Insulin \times Fasting\ Glucose}{22.5} \]

Where:

\( Fasting\ Insulin \) — Measured in μU/L (microinternational units per liter)
\( Fasting\ Glucose \) — Measured in mmol/L (millimoles per liter)
22.5 — Normalization constant derived from healthy population data

Explanation: The equation calculates insulin resistance by assessing the relationship between fasting insulin and glucose levels, with higher values indicating greater insulin resistance.

3. Importance of HOMA-IR Calculation

Details: HOMA-IR is a valuable tool for identifying insulin resistance, which is associated with type 2 diabetes, metabolic syndrome, and cardiovascular disease. Early detection allows for lifestyle interventions to prevent disease progression.

4. Using the Calculator

Tips: Enter fasting insulin in μU/L and fasting glucose in mmol/L. Both values must be obtained after an 8-12 hour fast for accurate results. All values must be valid (greater than 0).

5. Frequently Asked Questions (FAQ)

Q1: What is a normal HOMA-IR value?
A: Typically, values below 1.0 indicate normal insulin sensitivity. Values between 1.0-1.9 suggest early insulin resistance, while values above 2.0 indicate significant insulin resistance.

Q2: How does HOMA-IR compare to other insulin resistance tests?
A: HOMA-IR is simpler and less expensive than more complex tests like the hyperinsulinemic-euglycemic clamp (gold standard), but it provides a reasonable estimate for clinical purposes.

Q3: When should HOMA-IR be measured?
A: Morning fasting samples are essential. Avoid testing after illness, stress, or changes in medication that might affect glucose metabolism.

Q4: Are there limitations to HOMA-IR?
A: HOMA-IR may be less accurate in individuals with impaired beta-cell function, liver disease, or those using medications that affect insulin secretion or sensitivity.

Q5: Can HOMA-IR be used for diagnosis?
A: While HOMA-IR is a useful screening tool, diagnosis of insulin resistance should be confirmed with additional clinical assessment and possibly more definitive tests.