1. What is HOMA-B?

HOMA-B (Homeostatic Model Assessment for Beta Cell Function) is a mathematical model that estimates beta cell function from fasting plasma glucose and insulin levels. It provides an assessment of pancreatic beta cell function in the fasting state.

2. How Does the Calculator Work?

The calculator uses the HOMA-B equation:

Where:

• Fasting Insulin — Measured in μU/mL
• Fasting Glucose — Measured in mg/dL

Explanation: The equation estimates beta cell function as a percentage of normal, with 100% representing normal function. Higher values indicate better beta cell function.

3. Importance of HOMA-B Calculation

Details: HOMA-B is widely used in research and clinical practice to assess insulin secretion capacity and beta cell function, particularly in studies of diabetes and metabolic disorders.

4. Using the Calculator

Tips: Enter fasting insulin in μU/mL and fasting glucose in mg/dL. Both values must be greater than 0, and fasting glucose cannot be exactly 63 (as this would cause division by zero).

5. Frequently Asked Questions (FAQ)

Q1: What are normal HOMA-B values?
A: Normal HOMA-B values typically range from 80% to 120%, with 100% representing normal beta cell function.

Q2: How does HOMA-B differ from HOMA-IR?
A: HOMA-B assesses beta cell function, while HOMA-IR (Homeostatic Model Assessment of Insulin Resistance) estimates insulin resistance.

Q3: When should HOMA-B be measured?
A: HOMA-B should be calculated from fasting blood samples collected after an overnight fast of 8-12 hours.

Q4: Are there limitations to the HOMA-B model?
A: Yes, HOMA-B provides an estimate rather than a direct measurement and may be less accurate in certain populations or extreme metabolic conditions.

Q5: Can HOMA-B be used for diagnosis?
A: HOMA-B is primarily used for research and assessment purposes rather than clinical diagnosis. It should be interpreted in conjunction with other clinical findings.