HOMA-IR (CP) Calculator

HOMA-IR (CP) Equation:

\[ HOMA-IR (CP) = \frac{\text{Fasting Glucose} \times \text{Fasting C-Peptide}}{22.5} \]

HOMA-IR (CP):

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1. How Do You Calculate HOMA IR Using C Peptide?

The HOMA-IR (CP) (Homeostatic Model Assessment for Insulin Resistance using C-Peptide) is a method to estimate insulin resistance from fasting glucose and C-peptide levels. C-peptide is used as a marker of insulin secretion since it is produced in equimolar amounts to insulin but has a longer half-life.

2. How Does the Calculator Work?

The calculator uses the HOMA-IR (CP) equation:

\[ HOMA-IR (CP) = \frac{\text{Fasting Glucose} \times \text{Fasting C-Peptide}}{22.5} \]

Where:

Fasting Glucose — Measured in mmol/L
Fasting C-Peptide — Measured in nmol/L
22.5 — Normalization constant

Explanation: The equation provides an estimate of insulin resistance, with higher values indicating greater insulin resistance.

3. Importance of HOMA-IR Calculation

Details: HOMA-IR is a simple and widely used method to assess insulin resistance, which is a key factor in metabolic syndrome, type 2 diabetes, and cardiovascular disease risk assessment.

4. Using the Calculator

Tips: Enter fasting glucose in mmol/L and fasting C-peptide in nmol/L. Both values must be valid (greater than 0). The calculation requires an overnight fasting state for accurate results.

5. Frequently Asked Questions (FAQ)

Q1: Why use C-peptide instead of insulin for HOMA-IR?
A: C-peptide has a longer half-life than insulin and provides a more stable measurement of insulin secretion, making it particularly useful in certain clinical situations.

Q2: What are normal HOMA-IR (CP) values?
A: Normal values typically range from 0.5-1.4, though this may vary between populations and laboratories. Values above 2.0 often indicate significant insulin resistance.

Q3: When should HOMA-IR (CP) be measured?
A: After an overnight fast (8-12 hours), avoiding recent illness, surgery, or changes in medication that might affect glucose metabolism.

Q4: Are there limitations to this calculation?
A: Like the standard HOMA-IR, this version provides an estimate rather than a direct measurement of insulin resistance and may be less accurate in certain conditions such as liver disease or extreme BMI values.

Q5: How does HOMA-IR (CP) compare to the standard HOMA-IR?
A: Both assess insulin resistance, but the C-peptide version may be preferred when insulin assays are unreliable or when assessing beta-cell function in insulin-treated patients.