1. What is the HOMA2 Calculator?

The HOMA2 (Homeostatic Model Assessment 2) calculator is an updated computational model that estimates insulin resistance (HOMA2-IR), beta-cell function (HOMA2-%B), and insulin sensitivity (HOMA2-%S) from fasting glucose and insulin measurements.

2. How Does the Calculator Work?

The HOMA2 model uses a complex computational algorithm based on:

Key Outputs:

• HOMA2-IR - Insulin resistance index
• HOMA2-%B - Beta-cell function percentage
• HOMA2-%S - Insulin sensitivity percentage

3. Importance of HOMA2 Assessment

Details: HOMA2 assessment is crucial for evaluating metabolic health, identifying insulin resistance in prediabetes and type 2 diabetes, and monitoring response to treatment interventions.

4. Using the Calculator

Tips: Enter fasting insulin (μU/mL or pmol/L) and fasting glucose (mg/dL or mmol/L) values. Ensure measurements are taken after an 8-12 hour fast for accurate results.

5. Frequently Asked Questions (FAQ)

Q1: What is the difference between HOMA1 and HOMA2?
A: HOMA2 uses a more sophisticated computational model that provides separate estimates for insulin resistance, beta-cell function, and insulin sensitivity, while HOMA1 only estimates insulin resistance.

Q2: What are normal HOMA2 values?
A: Normal HOMA2-IR is typically <1.8, HOMA2-%B around 100%, and HOMA2-%S around 100%. Values may vary by population and laboratory.

Q3: When should HOMA2 testing be performed?
A: Morning fasting samples are essential. Avoid testing after illness, stress, or changes in medication that might affect glucose metabolism.

Q4: Are there limitations to the HOMA2 model?
A: The model assumes steady-state conditions and may be less accurate in certain populations including type 1 diabetes, pregnancy, or severe liver disease.

Q5: How often should HOMA2 be measured?
A: For monitoring purposes, every 3-6 months is typical, but frequency should be determined by your healthcare provider based on individual circumstances.