1. What is HOMA2-IR?

HOMA2-IR (Homeostatic Model Assessment 2 for Insulin Resistance) is an updated computational model that provides a more accurate assessment of insulin resistance and beta-cell function than the original HOMA1 model. It requires specialized software developed by the Oxford Centre for Diabetes, Endocrinology and Metabolism.

2. How Does the Calculator Work?

This calculator provides an approximation of HOMA2-IR using fasting insulin and glucose values. The actual HOMA2 model uses a complex computational method that:

• Models the interaction between glucose and insulin
• Accounts for hepatic and peripheral glucose resistance
• Includes beta-cell function assessment
• Requires specialized software for precise calculation

3. Importance of HOMA2-IR Calculation

Details: HOMA2-IR is used to assess insulin resistance in research and clinical settings. It helps identify individuals at risk for type 2 diabetes, metabolic syndrome, and cardiovascular disease, and can monitor response to treatment.

4. Using the Calculator

Tips: Enter fasting insulin (in μU/mL or pmol/L) and fasting glucose (in mg/dL or mmol/L). Values should be from the same blood draw after an 8-12 hour fast. This calculator provides an approximation; for research purposes, use the official Oxford HOMA2 calculator.

5. Frequently Asked Questions (FAQ)

Q1: Why use HOMA2 instead of HOMA1?
A: HOMA2 provides a more accurate assessment of insulin resistance and beta-cell function, with better modeling of the glucose-insulin feedback system.

Q2: What are normal HOMA2-IR values?
A: Typically, values below 1.0 indicate normal insulin sensitivity, while values above 1.8-2.0 suggest insulin resistance, though this varies by population.

Q3: When should insulin be measured?
A: Morning fasting sample is essential. Samples should be processed quickly as insulin is unstable in serum.

Q4: Are there limitations to HOMA2?
A: HOMA2 may be less accurate in extreme conditions (very high glucose, liver disease, type 1 diabetes) and doesn't account for dynamic postprandial changes.

Q5: Where can I find the official HOMA2 calculator?
A: The official HOMA2 calculator is available from the Oxford Centre for Diabetes, Endocrinology and Metabolism (www.dtu.ox.ac.uk/homacalculator).