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HOMA2 Model:
Computational model developed by Oxford University for assessing insulin resistance and beta-cell function
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The HOMA2 (Homeostatic Model Assessment 2) is a computational model developed by Oxford University that provides more accurate estimates of insulin resistance (HOMA2-IR) and beta-cell function (HOMA2-Beta) compared to the original HOMA1 model.
The calculator uses the Oxford University HOMA2 model which employs complex mathematical modeling based on fasting insulin and glucose levels to estimate:
Note: The actual HOMA2 calculation requires specialized software from Oxford University. This calculator provides an approximation for educational purposes.
Details: HOMA2 assessment is crucial for evaluating insulin resistance in metabolic disorders, diabetes research, and clinical studies. It provides more accurate results than the original HOMA1 model, especially in diabetic patients.
Tips: Enter fasting insulin (μU/mL or pmol/L) and fasting glucose (mg/dL or mmol/L) values. Ensure measurements are taken after an 8-12 hour fast for accurate results.
Q1: Why use HOMA2 instead of HOMA1?
A: HOMA2 provides more accurate estimates, especially in diabetic patients, and accounts for variations in hepatic and peripheral glucose resistance.
Q2: What are normal HOMA2 values?
A: Normal HOMA2-IR is typically <1.8-2.0. HOMA2-Beta normally ranges from 60-140% in healthy individuals.
Q3: When should insulin and glucose be measured?
A: Morning fasting samples after 8-12 hours of fasting provide the most reliable results for HOMA2 calculation.
Q4: Are there limitations to the HOMA2 model?
A: The model assumes steady-state conditions and may be less accurate in certain populations such as those with liver disease or extreme insulin levels.
Q5: Where can I get the official Oxford HOMA2 calculator?
A: The official HOMA2 calculator is available from the Diabetes Trials Unit at Oxford University (www.dtu.ox.ac.uk).