HOMA Index Calculator With C Peptide

HOMA-IR (CP) Equation:

\[ HOMA-IR (CP) = \frac{\text{Fasting Glucose} \times \text{Fasting C-Peptide}}{22.5} \]

HOMA-IR (CP):

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1. What is HOMA-IR (CP)?

HOMA-IR (CP) is a method for assessing insulin resistance using C-peptide measurements instead of insulin. It's part of the Homeostatic Model Assessment and provides an estimate of insulin resistance based on fasting glucose and C-peptide levels.

2. How Does the Calculator Work?

The calculator uses the HOMA-IR (CP) equation:

\[ HOMA-IR (CP) = \frac{\text{Fasting Glucose} \times \text{Fasting C-Peptide}}{22.5} \]

Where:

Fasting Glucose — Measured in mmol/L
Fasting C-Peptide — Measured in nmol/L
22.5 — Constant factor

Explanation: The equation estimates insulin resistance by considering the relationship between fasting glucose and C-peptide levels, which reflects insulin secretion.

3. Importance of HOMA-IR Calculation

Details: HOMA-IR is a valuable tool for assessing insulin resistance, which is associated with metabolic syndrome, type 2 diabetes, and cardiovascular disease risk. Using C-peptide instead of insulin can be advantageous in certain clinical situations.

4. Using the Calculator

Tips: Enter fasting glucose in mmol/L and fasting C-peptide in nmol/L. Both values must be greater than zero for accurate calculation.

5. Frequently Asked Questions (FAQ)

Q1: Why use C-peptide instead of insulin for HOMA-IR?
A: C-peptide has a longer half-life than insulin, providing a more stable measurement of insulin secretion, and isn't affected by hepatic extraction.

Q2: What are normal HOMA-IR values?
A: Normal HOMA-IR values typically range from 0.5-1.4, though this may vary between populations. Values above 2.0 often indicate significant insulin resistance.

Q3: When should HOMA-IR testing be performed?
A: Testing should be done after an overnight fast (8-12 hours) for accurate results.

Q4: Are there limitations to HOMA-IR calculation?
A: HOMA-IR provides an estimate rather than a direct measurement of insulin resistance and may be less accurate in certain conditions like liver disease or extreme obesity.

Q5: How does HOMA-IR (CP) compare to traditional HOMA-IR?
A: Both assess insulin resistance but use different biomarkers. HOMA-IR (CP) may be preferred when insulin assays are unavailable or when C-peptide measurements are more reliable.