1. What is the HOMA-IR Index?

The HOMA-IR (Homeostatic Model Assessment of Insulin Resistance) is a method used to quantify insulin resistance and beta-cell function. It provides an estimate of insulin resistance based on fasting glucose and insulin levels.

2. How Does the Calculator Work?

The calculator uses the HOMA-IR equation:

Where:

• Fasting Insulin — Measured in μU/mL
• Fasting Glucose — Measured in mg/dL

Explanation: The equation calculates insulin resistance by assessing the relationship between fasting insulin and glucose levels, with 405 as the normalization factor.

3. Importance of HOMA-IR Calculation

Details: HOMA-IR is crucial for assessing insulin resistance, which is associated with type 2 diabetes, metabolic syndrome, and cardiovascular diseases. It helps in early detection and monitoring of insulin resistance.

4. Using the Calculator

Tips: Enter fasting insulin in μU/mL and fasting glucose in mg/dL. Both values must be valid (greater than 0). For accurate results, measurements should be taken after an overnight fast.

5. Frequently Asked Questions (FAQ)

Q1: What is a normal HOMA-IR value?
A: Typically, HOMA-IR values below 2.5 are considered normal, though this may vary by population and laboratory standards.

Q2: Why use 405 in the denominator?
A: The value 405 is a normalization constant derived from empirical data to scale the result appropriately for clinical interpretation.

Q3: When should insulin and glucose be measured?
A: Measurements should be taken after an overnight fast (8-12 hours) for accurate assessment of fasting levels.

Q4: Are there limitations to HOMA-IR?
A: HOMA-IR is less accurate in individuals with impaired beta-cell function or those using medications that affect insulin secretion or sensitivity.

Q5: Can HOMA-IR be used for diagnosis?
A: While HOMA-IR is a useful screening tool, it should not be used alone for diagnosis. Clinical evaluation and other tests are necessary for definitive diagnosis.