1. What is the HOMA-IR Equation?

The HOMA-IR (Homeostatic Model Assessment for Insulin Resistance) equation estimates insulin resistance using fasting insulin and glucose levels. It provides a simple method to assess insulin sensitivity and identify potential metabolic disorders.

2. How Does the Calculator Work?

The calculator uses the HOMA-IR equation:

Where:

• \( Fasting\ Insulin \) — Fasting insulin level (μU/L)
• \( Fasting\ Glucose \) — Fasting glucose level (mmol/L)
• 22.5 — Normalization constant

Explanation: The equation calculates insulin resistance by assessing the relationship between fasting insulin and glucose levels, with higher values indicating greater insulin resistance.

3. Importance of HOMA-IR Calculation

Details: HOMA-IR is crucial for identifying insulin resistance, which is associated with type 2 diabetes, metabolic syndrome, and cardiovascular disease risk assessment.

4. Using the Calculator

Tips: Enter fasting insulin in μU/L and fasting glucose in mmol/L. Both values must be valid (greater than 0). Morning fasting samples provide the most accurate results.

5. Frequently Asked Questions (FAQ)

Q1: What are normal HOMA-IR values?
A: Normal HOMA-IR values are typically below 2.0, though this may vary by population. Values above 2.5 often indicate insulin resistance.

Q2: Why use mmol/L for glucose in this calculation?
A: The HOMA-IR equation was originally developed using mmol/L units for glucose to maintain consistency with international standards.

Q3: When should insulin and glucose be measured?
A: Morning fasting samples are essential for accurate HOMA-IR calculation. Avoid testing after meals or vigorous exercise.

Q4: Are there limitations to HOMA-IR?
A: HOMA-IR provides an estimate rather than a direct measure of insulin resistance and may be less accurate in certain populations like pregnant women or those with liver disease.

Q5: How often should HOMA-IR be calculated?
A: For monitoring purposes, HOMA-IR can be calculated during routine health check-ups or when assessing response to lifestyle interventions for insulin resistance.