1. What is HOMA-IR and HOMA-B?

HOMA (Homeostatic Model Assessment) is a method used to quantify insulin resistance (HOMA-IR) and beta-cell function (HOMA-B) from fasting insulin and glucose measurements. It provides valuable insights into metabolic health and diabetes risk assessment.

2. How Does the Calculator Work?

The calculator uses the HOMA equations:

Where:

• \( Fasting\ Insulin \) — Measured in μU/mL
• \( Fasting\ Glucose \) — Measured in mg/dL

Explanation: HOMA-IR estimates insulin resistance, while HOMA-B estimates beta-cell function based on fasting glucose and insulin levels.

3. Importance of HOMA Assessment

Details: HOMA assessment is crucial for evaluating insulin resistance, assessing diabetes risk, monitoring metabolic syndrome, and guiding treatment decisions for patients with impaired glucose metabolism.

4. Using the Calculator

Tips: Enter fasting insulin in μU/mL and fasting glucose in mg/dL. Both values must be valid positive numbers. For HOMA-B calculation, glucose must be greater than 63 mg/dL.

5. Frequently Asked Questions (FAQ)

Q1: What are normal HOMA-IR values?
A: Normal HOMA-IR values are typically below 2.0. Values above 2.0 may indicate insulin resistance, and above 2.5 suggest significant insulin resistance.

Q2: What do HOMA-B values indicate?
A: HOMA-B values estimate beta-cell function. Higher values indicate better beta-cell function. Normal values typically range between 100-200%.

Q3: When should these tests be performed?
A: Fasting insulin and glucose should be measured after an overnight fast (8-12 hours) for accurate results.

Q4: Are there limitations to HOMA calculations?
A: HOMA provides estimates rather than direct measurements and may be less accurate in certain populations or extreme metabolic conditions.

Q5: Can HOMA replace glucose tolerance tests?
A: While useful for screening, HOMA cannot replace comprehensive glucose tolerance tests for definitive diagnosis of diabetes or impaired glucose tolerance.