1. What is the HOMA-IR (CP) Equation?

The HOMA-IR (CP) (Homeostatic Model Assessment for Insulin Resistance using C-Peptide) equation estimates insulin resistance from fasting glucose and fasting C-peptide levels. It provides an alternative assessment when insulin measurements are not available.

2. How Does the Calculator Work?

The calculator uses the HOMA-IR (CP) equation:

Where:

• Fasting Glucose — Measured in mmol/L
• Fasting C-Peptide — Measured in nmol/L
• 22.5 — Constant normalization factor

Explanation: The equation calculates insulin resistance by considering the product of fasting glucose and C-peptide levels, normalized by a constant factor.

3. Importance of HOMA-IR Calculation

Details: HOMA-IR is crucial for assessing insulin resistance, which is associated with metabolic syndrome, type 2 diabetes, and cardiovascular diseases.

4. Using the Calculator

Tips: Enter fasting glucose in mmol/L and fasting C-peptide in nmol/L. Both values must be valid (greater than 0).

5. Frequently Asked Questions (FAQ)

Q1: Why use C-peptide instead of insulin?
A: C-peptide has a longer half-life and more stable levels than insulin, providing a more reliable measurement in some clinical situations.

Q2: What are normal HOMA-IR values?
A: Normal HOMA-IR values typically range from 1.0 to 1.5, though this may vary between populations and laboratories.

Q3: When should glucose and C-peptide be measured?
A: Both should be measured after an overnight fast (8-12 hours) for accurate results.

Q4: Are there limitations to this equation?
A: The equation may be less accurate in extreme conditions such as severe insulin resistance or beta-cell dysfunction.

Q5: Can this calculator be used for diagnosis?
A: This calculator provides an estimate and should not be used as the sole basis for diagnosis. Always consult with a healthcare professional.