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HOMA2 Model:
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The HOMA2 (Homeostatic Model Assessment 2) is an updated computational model developed by Oxford University that provides more accurate estimates of insulin resistance (HOMA2-IR), beta-cell function (HOMA2-%B), and insulin sensitivity (HOMA2-%S) compared to the original HOMA1 model.
The HOMA2 model uses a sophisticated computational approach that requires specialized software from Oxford University. It takes fasting insulin and glucose measurements and solves a set of differential equations that model the glucose-insulin feedback system in the human body.
Key Outputs:
Details: The HOMA2 model provides valuable insights into metabolic health, helping to identify insulin resistance early, assess diabetes risk, and monitor treatment effectiveness in metabolic disorders.
Tips: Enter fasting insulin (μU/mL or pmol/L) and fasting glucose (mg/dL or mmol/L) values. For accurate results, measurements should be taken after an overnight fast of 8-12 hours.
Q1: Why is the Oxford HOMA2 calculator different?
A: The HOMA2 model uses a complex computational approach rather than a simple formula, providing more accurate estimates that account for the non-linear relationships between insulin and glucose.
Q2: How do I access the actual Oxford HOMA2 calculator?
A: The official HOMA2 calculator is available through the University of Oxford Diabetes Trials Unit website and requires software download or online access.
Q3: What are normal HOMA2 values?
A: Normal HOMA2-IR is typically around 1.0, with values above 1.8-2.0 indicating insulin resistance. Normal ranges may vary by population and laboratory.
Q4: When should HOMA2 testing be performed?
A: Testing should be done after an overnight fast, avoiding recent illness, medication changes, or unusual physical activity that might affect results.
Q5: Are there limitations to the HOMA2 model?
A: While more accurate than HOMA1, HOMA2 still has limitations in extreme obesity, liver disease, and other conditions that affect glucose metabolism.