1. What is the HOMA-IR Calculator?

The HOMA-IR (Homeostatic Model Assessment for Insulin Resistance) calculator estimates insulin resistance using fasting insulin and glucose levels. It provides a quantitative measure of insulin sensitivity and is widely used in clinical research and practice.

2. How Does the Calculator Work?

The calculator uses the HOMA-IR equation:

Where:

• \( Fasting\ Insulin \) — Fasting insulin level (μU/mL)
• \( Fasting\ Glucose \) — Fasting glucose level (mg/dL)

Explanation: The equation calculates insulin resistance by assessing the relationship between fasting insulin and glucose levels, with higher values indicating greater insulin resistance.

3. Importance of HOMA-IR Calculation

Details: HOMA-IR is crucial for assessing insulin resistance, which is associated with metabolic syndrome, type 2 diabetes, cardiovascular disease, and other metabolic disorders.

4. Using the Calculator

Tips: Enter fasting insulin in μU/mL and fasting glucose in mg/dL. Both values must be valid (greater than 0). For accurate results, measurements should be taken after an overnight fast.

5. Frequently Asked Questions (FAQ)

Q1: What is a normal HOMA-IR value?
A: Normal HOMA-IR values typically range from 0.5 to 1.4. Values above 2.0 indicate significant insulin resistance, while values above 2.5 suggest severe insulin resistance.

Q2: How does HOMA-IR differ from other insulin resistance measures?
A: HOMA-IR is a simple, non-invasive method that uses fasting values only, making it more practical for clinical use compared to more complex tests like the hyperinsulinemic-euglycemic clamp.

Q3: When should HOMA-IR be measured?
A: HOMA-IR should be measured after an overnight fast (8-12 hours) for accurate results. Avoid testing after meals or strenuous exercise.

Q4: Are there limitations to the HOMA-IR calculation?
A: HOMA-IR may be less accurate in individuals with impaired beta-cell function, type 1 diabetes, or those using medications that affect insulin secretion or sensitivity.

Q5: Can HOMA-IR be used for diagnosis?
A: While HOMA-IR is a useful screening tool for insulin resistance, it should not be used alone for diagnosis. Clinical correlation and additional testing are recommended for definitive diagnosis.