1. What is the HOMA-IR Calculation?

The HOMA-IR (Homeostatic Model Assessment for Insulin Resistance) is a method used to quantify insulin resistance and beta-cell function. It provides an estimate of insulin resistance from fasting insulin and glucose measurements, with insulin converted from pmol/L to μU/L.

2. How Does the Calculator Work?

The calculator uses the HOMA-IR equation:

Where:

• \( Fasting\ Insulin \) — Insulin level in pmol/L
• \( Fasting\ Glucose \) — Glucose level in mmol/L
• \( /6 \) — Conversion factor from pmol/L to μU/L
• \( 22.5 \) — Normalization constant

Explanation: The equation calculates insulin resistance by assessing the relationship between fasting insulin and glucose levels, with appropriate unit conversions.

3. Importance of HOMA-IR Assessment

Details: HOMA-IR is crucial for identifying insulin resistance, which is associated with metabolic syndrome, type 2 diabetes, and cardiovascular disease risk assessment.

4. Using the Calculator

Tips: Enter fasting insulin in pmol/L and fasting glucose in mmol/L. Both values must be valid (greater than 0). Use morning fasting samples for accurate results.

5. Frequently Asked Questions (FAQ)

Q1: What is a normal HOMA-IR value?
A: Typically, values below 1.0 indicate normal insulin sensitivity, while values above 2.0 suggest significant insulin resistance.

Q2: Why convert insulin from pmol/L to μU/L?
A: The original HOMA-IR formula was developed using μU/L units, so conversion is necessary when using pmol/L measurements.

Q3: When should insulin and glucose be measured?
A: Morning fasting samples are essential after an 8-12 hour overnight fast for accurate assessment.

Q4: Are there limitations to HOMA-IR?
A: While useful for population studies, it may be less accurate in individuals with impaired glucose tolerance or diabetes.

Q5: Can HOMA-IR be used for diagnosis?
A: HOMA-IR is a screening tool and should be used alongside other clinical assessments rather than as a sole diagnostic criterion.