1. What is HOMA-IR (CP)?

HOMA-IR (CP) is a variation of the Homeostatic Model Assessment for Insulin Resistance that uses C-peptide instead of insulin levels. It provides an estimate of insulin resistance, which is a key factor in metabolic disorders like type 2 diabetes.

2. How Does the Calculator Work?

The calculator uses the HOMA-IR (CP) equation:

Where:

• Fasting Glucose — Measured in mmol/L
• Fasting C-Peptide — Measured in nmol/L
• 22.5 — Constant denominator

Explanation: The equation calculates insulin resistance by combining fasting glucose and C-peptide levels, providing an alternative to traditional insulin-based HOMA-IR calculations.

3. Importance of HOMA-IR Calculation

Details: Assessing insulin resistance is crucial for diagnosing metabolic syndrome, predicting diabetes risk, and monitoring treatment effectiveness in patients with insulin resistance disorders.

4. Using the Calculator

Tips: Enter fasting glucose in mmol/L and fasting C-peptide in nmol/L. Both values must be valid (greater than 0). For accurate results, measurements should be taken after an overnight fast.

5. Frequently Asked Questions (FAQ)

Q1: Why use C-peptide instead of insulin?
A: C-peptide has a longer half-life than insulin, providing a more stable measurement of beta-cell function and insulin secretion.

Q2: What are normal HOMA-IR (CP) values?
A: Normal values typically range from 0.5-1.4, though this may vary by population. Values above 1.9 may indicate insulin resistance.

Q3: When should HOMA-IR (CP) be measured?
A: Morning fasting samples are essential. Avoid testing after meals or during acute illness for accurate results.

Q4: Are there limitations to this calculation?
A: The equation may be less accurate in extreme cases of insulin resistance or in patients with liver disease or renal impairment.

Q5: How does this compare to traditional HOMA-IR?
A: HOMA-IR (CP) provides comparable results to insulin-based HOMA-IR but may be preferred when insulin assays are unavailable or unreliable.