HOMA IR Calculation Mice

HOMA-IR Formula:

\[ HOMA-IR = \frac{\text{Fasting Insulin} \times \text{Fasting Glucose}}{22.5} \]

HOMA-IR Score:

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1. What is HOMA-IR?

HOMA-IR (Homeostatic Model Assessment for Insulin Resistance) is a method used to quantify insulin resistance and beta-cell function. While originally developed for humans, the same formula is commonly used for mice research with mmol/L units.

2. How Does the Calculator Work?

The calculator uses the HOMA-IR formula:

\[ HOMA-IR = \frac{\text{Fasting Insulin} \times \text{Fasting Glucose}}{22.5} \]

Where:

Fasting Insulin — Measured in μU/L (microinternational units per liter)
Fasting Glucose — Measured in mmol/L (millimoles per liter)
22.5 — Normalization constant

Explanation: The equation provides a simple mathematical model that estimates insulin resistance from fasting insulin and glucose levels.

3. Importance of HOMA-IR Calculation

Details: HOMA-IR is widely used in research settings to assess insulin resistance in mouse models, particularly in diabetes and metabolic syndrome studies. It provides a non-invasive method to evaluate metabolic health.

4. Using the Calculator

Tips: Enter fasting insulin in μU/L and fasting glucose in mmol/L. Both values must be positive numbers obtained from proper fasting blood samples.

5. Frequently Asked Questions (FAQ)

Q1: Why use the same formula for mice as humans?
A: The HOMA-IR formula has been validated and widely adopted for mouse studies using mmol/L units, providing consistent methodology across species for comparative research.

Q2: What are typical HOMA-IR values in mice?
A: Normal HOMA-IR values vary by strain, age, and diet. Generally, values below 2.0 indicate normal insulin sensitivity, while higher values suggest insulin resistance.

Q3: When should samples be collected?
A: Blood samples should be collected after an appropriate fasting period (typically 4-6 hours for mice) to ensure accurate fasting insulin and glucose measurements.

Q4: Are there limitations to HOMA-IR in mice?
A: While useful for screening, HOMA-IR is an estimate and may not capture all aspects of insulin resistance. Hyperinsulinemic-euglycemic clamps provide more direct measurements.

Q5: Can HOMA-IR be used for longitudinal studies?
A: Yes, HOMA-IR is particularly valuable for tracking changes in insulin resistance over time in the same animals or across treatment groups.