1. What is HOMA-IR?

HOMA-IR (Homeostatic Model Assessment for Insulin Resistance) is a method used to quantify insulin resistance and beta-cell function from fasting blood glucose and insulin levels.

2. How Does the Calculator Work?

The calculator uses the HOMA-IR equation:

Where:

• Fasting Insulin — Measured in micro units per milliliter (μU/mL)
• Fasting Glucose — Measured in milligrams per deciliter (mg/dL)
• 405 — Constant used for normalization

Explanation: The equation provides a simple way to estimate insulin resistance from basic fasting blood measurements.

3. Importance of HOMA-IR Calculation

Details: HOMA-IR is widely used in clinical research and practice to assess insulin resistance, which is associated with metabolic syndrome, type 2 diabetes, and cardiovascular disease risk.

4. Using the Calculator

Tips: Enter fasting insulin in μU/mL and fasting glucose in mg/dL. Both values must be valid (greater than 0). For accurate results, measurements should be taken after an overnight fast.

5. Frequently Asked Questions (FAQ)

Q1: What is a normal HOMA-IR value?
A: Typically, values below 2.0 are considered normal, though this may vary by population and laboratory standards.

Q2: How does HOMA-IR relate to diabetes risk?
A: Higher HOMA-IR values indicate greater insulin resistance, which is a major risk factor for developing type 2 diabetes.

Q3: When should HOMA-IR testing be done?
A: Testing should be performed after an overnight fast of 8-12 hours for accurate results.

Q4: Are there limitations to HOMA-IR?
A: While useful for population studies, HOMA-IR may not be as accurate as more complex tests like hyperinsulinemic-euglycemic clamps for individual assessment.

Q5: Can HOMA-IR be used to monitor treatment?
A: Yes, HOMA-IR can be used to monitor the effectiveness of interventions aimed at improving insulin sensitivity, such as lifestyle changes or medications.