HOMA-IR Equation:
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HOMA-IR (Homeostatic Model Assessment for Insulin Resistance) is a method used to quantify insulin resistance and beta-cell function. It provides an estimate of insulin sensitivity based on fasting insulin and glucose levels.
The calculator uses the HOMA-IR equation:
Where:
Explanation: The equation calculates insulin resistance by assessing the relationship between fasting insulin and glucose levels.
Details: HOMA-IR is crucial for assessing insulin resistance, which is associated with metabolic syndrome, type 2 diabetes, cardiovascular disease, and other metabolic disorders.
Tips: Enter fasting insulin in μU/mL and fasting glucose in mg/dL. Both values must be valid (greater than 0). For accurate results, use values from morning fasting blood tests.
Q1: What are normal HOMA-IR values?
A: Typically, values below 1.0 indicate normal insulin sensitivity. Values between 1.0-2.0 suggest mild insulin resistance, while values above 2.0 indicate significant insulin resistance.
Q2: When should insulin and glucose be measured?
A: Morning fasting samples are essential for accurate HOMA-IR calculation. Avoid testing after meals or strenuous exercise.
Q3: Are there limitations to HOMA-IR?
A: HOMA-IR is an estimate and may not be as accurate as more complex tests like hyperinsulinemic-euglycemic clamp, but it's widely used due to its simplicity.
Q4: Can HOMA-IR be used for diagnosis?
A: While HOMA-IR is a useful screening tool, clinical diagnosis should be based on comprehensive evaluation including other tests and clinical assessment.
Q5: How often should HOMA-IR be measured?
A: Frequency depends on individual risk factors and clinical context. Typically monitored every 6-12 months for at-risk individuals or those undergoing treatment.