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HOMA2 Model:
Computational model requiring specialized software - no simple algebraic formula available
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The HOMA2 (Homeostatic Model Assessment 2) is an updated computational model that provides a more accurate assessment of insulin resistance and beta-cell function than the original HOMA1 model. It uses fasting insulin and glucose levels to estimate insulin sensitivity.
The HOMA2 model is a complex computational algorithm that requires specialized software. Unlike the original HOMA1 formula, there is no simple algebraic equation for HOMA2-IR calculation.
Key Features:
Details: HOMA2-IR is a valuable tool for assessing insulin resistance in research and clinical settings. It helps identify individuals at risk for type 2 diabetes, metabolic syndrome, and cardiovascular disease, and can monitor response to interventions.
Tips: Enter fasting insulin (μU/mL or pmol/L) and fasting glucose (mg/dL or mmol/L) values. Ensure samples are collected after an 8-12 hour fast for accurate results.
Q1: Why use HOMA2 instead of HOMA1?
A: HOMA2 provides more accurate estimates across a wider range of insulin sensitivity and uses a computational model that better reflects human physiology.
Q2: What are normal HOMA2-IR values?
A: Typically, HOMA2-IR values below 1.0 indicate normal insulin sensitivity, while values above 1.8-2.0 suggest insulin resistance.
Q3: When should insulin be measured?
A: Morning fasting sample is essential. Avoid testing after recent illness, surgery, or medication changes that affect glucose metabolism.
Q4: Are there limitations to HOMA2?
A: Like all models, HOMA2 has limitations. It may be less accurate in certain populations such as those with type 1 diabetes, liver disease, or extreme obesity.
Q5: Where can I find the official HOMA2 calculator?
A: The official HOMA2 calculator is available through the University of Oxford Diabetes Trials Unit website for research purposes.