HOMA Calculator Oxford University

HOMA2 Model:

Computational model developed by Oxford University Diabetes Trial Unit

Note: This calculator uses the HOMA2 model which requires specialized software

HOMA2-IR (Approximation):

HOMA2-Beta (Approximation):

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1. What is the HOMA Calculator?

The HOMA (Homeostatic Model Assessment) Calculator from Oxford University is a computational model that estimates insulin resistance (HOMA2-IR) and beta-cell function (HOMA2-Beta) from fasting glucose and insulin measurements.

2. How Does the Calculator Work?

The calculator uses the HOMA2 model developed by the Oxford Centre for Diabetes, Endocrinology and Metabolism:

Computational model requiring specialized software

Note: This online version provides an approximation based on published algorithms

Input Parameters:

Fasting Insulin (μU/mL or pmol/L)
Fasting Glucose (mg/dL or mmol/L)

Output Values:

HOMA2-IR - Insulin resistance index
HOMA2-Beta - Beta-cell function percentage

3. Importance of HOMA2 Assessment

Details: The HOMA2 model provides a more accurate assessment of insulin resistance and beta-cell function compared to the original HOMA1 model, particularly across a wider range of glucose tolerance states.

4. Using the Calculator

Tips: Enter fasting insulin and glucose values with appropriate units. For accurate results, measurements should be taken after an overnight fast of 8-12 hours.

5. Frequently Asked Questions (FAQ)

Q1: What is the difference between HOMA1 and HOMA2?
A: HOMA2 uses a computer-based model that provides more accurate estimates across different glucose tolerance states and includes corrections for variations in hepatic and peripheral glucose resistance.

Q2: What are normal HOMA2 values?
A: Normal HOMA2-IR is typically 1.0, with values above 1.8-2.0 indicating insulin resistance. Normal HOMA2-Beta is around 100%.

Q3: When should HOMA2 be used?
A: HOMA2 is useful for research studies, clinical trials, and assessment of insulin resistance in clinical practice when more complex methods are not available.

Q4: Are there limitations to the HOMA2 model?
A: The model assumes steady-state conditions and may be less accurate in conditions with rapidly changing glucose levels or in patients with liver disease.

Q5: Where can I find the official HOMA2 calculator?
A: The official HOMA2 calculator is available from the University of Oxford Diabetes Trials Unit website for research and clinical use.