1. What is the HOMA-IR Formula?

The HOMA-IR (Homeostatic Model Assessment of Insulin Resistance) is a method used to quantify insulin resistance and beta-cell function. It provides a simple way to assess insulin resistance from fasting glucose and insulin measurements.

2. How Does the Calculator Work?

The calculator uses the HOMA-IR equation:

Where:

• \( Fasting\ Insulin \) — Fasting insulin level (μU/mL)
• \( Fasting\ Glucose \) — Fasting glucose level (mg/dL)
• 405 — Normalization constant

Explanation: The equation calculates insulin resistance by assessing the relationship between fasting insulin and glucose levels, with higher values indicating greater insulin resistance.

3. Importance of HOMA-IR Calculation

Details: HOMA-IR is widely used in clinical research and practice to identify insulin resistance, which is associated with metabolic syndrome, type 2 diabetes, and cardiovascular disease risk.

4. Using the Calculator

Tips: Enter fasting insulin in μU/mL and fasting glucose in mg/dL. Both values must be valid (greater than 0). Morning fasting samples provide the most accurate results.

5. Frequently Asked Questions (FAQ)

Q1: What is a normal HOMA-IR value?
A: Typically, values below 2.0 are considered normal, though this may vary by population and laboratory standards.

Q2: How does HOMA-IR relate to diabetes risk?
A: Higher HOMA-IR values indicate greater insulin resistance, which is a major risk factor for developing type 2 diabetes.

Q3: When should insulin and glucose be measured?
A: Morning fasting samples after an 8-12 hour fast provide the most accurate results for HOMA-IR calculation.

Q4: Are there limitations to HOMA-IR?
A: While useful for population studies, HOMA-IR may be less accurate in individuals with extreme insulin resistance or beta-cell dysfunction.

Q5: Can HOMA-IR be used for diagnosis?
A: HOMA-IR is primarily a research tool and screening measure rather than a diagnostic test for insulin resistance.