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HOMA-IR (CP) Equation:
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HOMA-IR (CP) is the Homeostatic Model Assessment for Insulin Resistance using C-peptide instead of insulin. It provides an estimate of insulin resistance based on fasting glucose and C-peptide levels.
The calculator uses the HOMA-IR (CP) equation:
Where:
Explanation: This equation calculates insulin resistance by assessing the relationship between fasting glucose and C-peptide levels, providing an alternative to insulin-based HOMA calculations.
Details: HOMA-IR is a valuable tool for assessing insulin resistance, which is associated with various metabolic disorders including type 2 diabetes, metabolic syndrome, and cardiovascular diseases.
Tips: Enter fasting glucose in mmol/L and fasting C-peptide in nmol/L. Both values must be valid (greater than 0). For accurate results, measurements should be taken after an overnight fast.
Q1: Why use C-peptide instead of insulin?
A: C-peptide has a longer half-life than insulin and provides a more stable measurement of insulin secretion, making it useful when insulin assays are unavailable or unreliable.
Q2: What are normal HOMA-IR values?
A: Normal HOMA-IR values typically range from 0.5-1.4, though this may vary by population. Values above 2.0 generally indicate significant insulin resistance.
Q3: When should these tests be performed?
A: Tests should be performed after an overnight fast (8-12 hours) for accurate results. Avoid testing after meals or strenuous exercise.
Q4: Are there limitations to this calculation?
A: Like all HOMA models, this provides an estimate rather than a direct measurement of insulin resistance and may be less accurate in certain populations.
Q5: How does this compare to the standard HOMA-IR?
A: The C-peptide version correlates well with the insulin-based HOMA-IR and provides comparable assessment of insulin resistance.