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HOMA-IR Formula:
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The HOMA (Homeostatic Model Assessment) formula calculates insulin resistance using fasting insulin and glucose levels. HOMA-IR is a simple and widely used method to assess insulin sensitivity in clinical and research settings.
The calculator uses the HOMA-IR formula:
Where:
Explanation: The formula estimates insulin resistance by calculating the product of fasting insulin and glucose levels, normalized by a constant factor.
Details: HOMA-IR is crucial for identifying insulin resistance, which is associated with type 2 diabetes, metabolic syndrome, and cardiovascular diseases. It helps in early detection and monitoring of metabolic health.
Tips: Enter fasting insulin in μU/mL and fasting glucose in mg/dL. Both values must be valid (greater than 0). For accurate results, use values from a true fasting state (8-12 hours without food).
Q1: What is a normal HOMA-IR value?
A: Typically, HOMA-IR values below 1.0 indicate normal insulin sensitivity, values between 1.0-2.0 suggest mild insulin resistance, and values above 2.0 indicate significant insulin resistance.
Q2: Are there different HOMA formulas?
A: Yes, there are variations including HOMA-%B (beta cell function) and HOMA-%S (insulin sensitivity), but HOMA-IR is the most commonly used for insulin resistance assessment.
Q3: When should HOMA-IR be measured?
A: Ideally after an overnight fast of 8-12 hours. Avoid testing after illness, stress, or changes in medication that might affect glucose or insulin levels.
Q4: What are the limitations of HOMA-IR?
A: HOMA-IR provides an estimate rather than a direct measurement. It may be less accurate in certain populations such as those with type 1 diabetes, liver disease, or extremely high insulin levels.
Q5: Can HOMA-IR be used for diagnosis?
A: While HOMA-IR is a useful screening tool, clinical diagnosis of insulin resistance should be confirmed with additional tests and clinical evaluation by a healthcare professional.