1. What is the HOMA-Beta Calculation?

The HOMA-Beta (Homeostatic Model Assessment for Beta Cell Function) estimates pancreatic beta-cell function from fasting insulin and glucose levels. It provides insight into insulin secretion capacity and is used in diabetes research and clinical assessment.

2. How Does the Calculator Work?

The calculator uses the HOMA-Beta formula:

Where:

• Fasting Insulin — Measured in μU/L
• Fasting Glucose — Measured in mmol/L

Explanation: The formula calculates beta-cell function based on the relationship between fasting insulin and glucose levels, with 3.5 representing the theoretical fasting glucose level at which insulin secretion is zero.

3. Importance of HOMA-Beta

Details: HOMA-Beta is crucial for assessing insulin secretion capacity, identifying beta-cell dysfunction in prediabetes and diabetes, and monitoring treatment effects on pancreatic function.

4. Using the Calculator

Tips: Enter fasting insulin in μU/L and fasting glucose in mmol/L. Both values must be valid positive numbers, and glucose cannot be exactly 3.5 (to avoid division by zero).

5. Frequently Asked Questions (FAQ)

Q1: What are normal HOMA-Beta values?
A: Normal values typically range between 100-200%, though this can vary by population and laboratory methods.

Q2: How does HOMA-Beta differ from HOMA-IR?
A: HOMA-Beta assesses beta-cell function (insulin secretion), while HOMA-IR assesses insulin resistance.

Q3: When should HOMA-Beta be measured?
A: After an overnight fast (8-12 hours), avoiding recent illness, stress, or medication changes that affect glucose metabolism.

Q4: Are there limitations to HOMA-Beta?
A: Less accurate in extreme glucose levels, type 1 diabetes, and conditions with abnormal insulin secretion patterns.

Q5: Can HOMA-Beta be used for diagnosis?
A: It's primarily a research tool and screening assessment, not a standalone diagnostic test for diabetes.