1. What is HOMA-B?

HOMA-B (Homeostatic Model Assessment for Beta Cell Function) is a mathematical model that estimates pancreatic beta-cell function from fasting glucose and insulin concentrations. It provides an assessment of insulin secretion capacity.

2. How Does the Calculator Work?

The calculator uses the HOMA-B equation:

Where:

• Fasting Insulin — Measured in μU/mL
• Fasting Glucose — Measured in mg/dL

Explanation: The equation estimates beta-cell function as a percentage of normal, with 100% representing normal function.

3. Importance of HOMA-B Calculation

Details: HOMA-B is widely used in research and clinical practice to assess insulin secretion capacity, monitor beta-cell function in diabetes progression, and evaluate response to treatments that affect insulin secretion.

4. Using the Calculator

Tips: Enter fasting insulin in μU/mL and fasting glucose in mg/dL. Both values must be positive, and glucose must be greater than 63 mg/dL for valid calculation.

5. Frequently Asked Questions (FAQ)

Q1: What is a normal HOMA-B value?
A: Normal HOMA-B values typically range between 70-110%, representing normal beta-cell function.

Q2: How does HOMA-B relate to diabetes?
A: Lower HOMA-B values indicate impaired beta-cell function, which is characteristic of type 2 diabetes.

Q3: When should HOMA-B testing be done?
A: Testing should be performed after an overnight fast (8-12 hours) for accurate results.

Q4: Are there limitations to HOMA-B?
A: HOMA-B provides an estimate rather than a direct measurement and may be less accurate in extreme insulin resistance or advanced diabetes.

Q5: How often should HOMA-B be measured?
A: Frequency depends on clinical context, but it's typically used for initial assessment and monitoring treatment response every 3-6 months.