1. What is HOMA-B?

HOMA-B (Homeostatic Model Assessment for Beta Cell Function) is a mathematical model that estimates beta cell function from fasting glucose and insulin levels. It provides an assessment of pancreatic beta cell function and insulin secretion capacity.

2. How Does the Calculator Work?

The calculator uses the HOMA-B formula:

Where:

• Fasting Insulin — Measured in μU/mL
• Fasting Glucose — Measured in mg/dL

Explanation: The formula calculates beta cell function as a percentage of normal, with 100% representing normal function. Higher values indicate better beta cell function.

3. Importance of HOMA-B Calculation

Details: HOMA-B is used in research and clinical practice to assess insulin secretion capacity, monitor progression of diabetes, and evaluate treatment effectiveness in preserving beta cell function.

4. Using the Calculator

Tips: Enter fasting insulin in μU/mL and fasting glucose in mg/dL. Both values must be positive numbers, and glucose must be greater than 63 mg/dL for valid calculation.

5. Frequently Asked Questions (FAQ)

Q1: What are normal HOMA-B values?
A: Normal HOMA-B values typically range from 80% to 120%, with 100% representing normal beta cell function.

Q2: When should HOMA-B be measured?
A: HOMA-B should be measured from true fasting samples (8-12 hours fasting) in the morning for accurate results.

Q3: What does a low HOMA-B value indicate?
A: Low HOMA-B values indicate impaired beta cell function and reduced insulin secretion capacity, often seen in type 2 diabetes.

Q4: Are there limitations to HOMA-B?
A: HOMA-B provides an estimate rather than direct measurement and may be less accurate in certain populations including those with very high or very low insulin levels.

Q5: How often should HOMA-B be monitored?
A: Monitoring frequency depends on clinical context, but typically it's assessed at diagnosis and during treatment adjustments for diabetes management.