1. What is the HOMA2 Calculator?

The HOMA2 (Homeostatic Model Assessment 2) calculator is an updated computational model that estimates beta cell function (HOMA2-B) and insulin resistance (HOMA2-IR) from fasting glucose and insulin measurements.

2. How Does the Calculator Work?

The HOMA2 model uses a computational approach rather than a simple algebraic formula. It requires specialized software or online calculators from the Oxford Centre for Diabetes, Endocrinology and Metabolism.

Input Parameters:

• Fasting Insulin (μU/mL or pmol/L)
• Fasting Glucose (mg/dL or mmol/L)

Output: HOMA2-B (beta cell function) and HOMA2-IR (insulin resistance) indices

3. Importance of HOMA2-B Calculation

Details: HOMA2-B provides a more accurate assessment of beta cell function compared to the original HOMA model. It's widely used in research and clinical studies to evaluate pancreatic beta cell function in diabetes and metabolic disorders.

4. Using the Calculator

Tips: Enter fasting insulin and glucose values. For accurate results, measurements should be taken after an overnight fast. Use consistent units (μU/mL for insulin, mg/dL for glucose).

5. Frequently Asked Questions (FAQ)

Q1: Why is HOMA2 better than the original HOMA?
A: HOMA2 uses a computational model that provides more accurate estimates across a wider range of glucose and insulin values, and better reflects human physiology.

Q2: What are normal HOMA2-B values?
A: Normal HOMA2-B values typically range from 70-110% in healthy individuals, though this can vary by population and laboratory.

Q3: When should insulin and glucose be measured?
A: Morning fasting samples are essential. Avoid testing after meals, stress, or medication that affects glucose metabolism.

Q4: Are there limitations to the HOMA2 model?
A: The model assumes steady-state conditions and may be less accurate in certain populations such as those with type 1 diabetes or extreme insulin resistance.

Q5: Where can I access the official HOMA2 calculator?
A: The official HOMA2 calculator is available through the Oxford Centre for Diabetes, Endocrinology and Metabolism website.