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HOMA2 Model:
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HOMA2-B (Homeostatic Model Assessment 2 for Beta Cell Function) is an updated computational model that estimates pancreatic beta-cell function from fasting insulin and glucose measurements. It provides a more accurate assessment than the original HOMA model.
The calculator uses the Oxford HOMA2 computational model which involves complex mathematical calculations rather than a simple formula. The model accounts for the non-linear relationship between insulin secretion and glucose levels.
Note: The actual HOMA2 model requires specialized software from the University of Oxford. This calculator provides an approximation based on established mathematical relationships.
Details: HOMA2-B is crucial for assessing pancreatic beta-cell function in diabetes research, evaluating insulin secretion capacity, and monitoring changes in beta-cell function over time or with treatment.
Tips: Enter fasting insulin (μU/mL or pmol/L) and fasting glucose (mg/dL or mmol/L) values. Ensure measurements are taken after an overnight fast for accurate results.
Q1: What are normal HOMA2-B values?
A: Normal HOMA2-B values typically range from 70-140% in healthy individuals, though this can vary based on age and other factors.
Q2: How does HOMA2-B differ from the original HOMA-B?
A: HOMA2 uses a more sophisticated computational model that provides better accuracy, especially at extreme values, and accounts for variations in hepatic and peripheral glucose metabolism.
Q3: When should HOMA2-B be measured?
A: Morning fasting samples are essential. Avoid testing after recent illness, steroid use, or significant changes in diet/exercise routine.
Q4: Are there limitations to HOMA2-B?
A: The model assumes steady-state conditions and may be less accurate in certain populations such as those with liver disease, renal impairment, or extreme obesity.
Q5: Where can I get the official HOMA2 software?
A: The official HOMA2 calculator is available from the University of Oxford Diabetes Trial Unit for research purposes.