1. What is the HOMA-IR Equation?

The HOMA-IR (Homeostatic Model Assessment for Insulin Resistance) equation estimates insulin resistance using fasting insulin and glucose levels. It provides a simple method to assess insulin sensitivity and identify individuals at risk for metabolic disorders.

2. How Does the Calculator Work?

The calculator uses the HOMA-IR equation:

Where:

• Fasting Insulin — Measured in μU/L
• Fasting Glucose — Measured in mmol/L
• 22.5 — Normalization constant

Explanation: The equation calculates insulin resistance by multiplying fasting insulin and glucose levels, then dividing by the normalization constant 22.5.

3. Importance of HOMA-IR Calculation

Details: HOMA-IR is crucial for assessing insulin resistance, which is associated with type 2 diabetes, metabolic syndrome, and cardiovascular disease. It helps in early detection and monitoring of insulin sensitivity.

4. Using the Calculator

Tips: Enter fasting insulin in μU/L and fasting glucose in mmol/L. Both values must be valid (greater than 0). The calculator will compute the HOMA-IR score.

5. Frequently Asked Questions (FAQ)

Q1: What is a normal HOMA-IR value?
A: Normal HOMA-IR values are typically below 2.0. Values above 2.0 may indicate insulin resistance.

Q2: When should insulin and glucose be measured?
A: Both should be measured after an 8-12 hour fast for accurate results.

Q3: Are there limitations to the HOMA-IR equation?
A: HOMA-IR is less accurate in individuals with impaired beta-cell function or those using medications that affect insulin secretion.

Q4: Can HOMA-IR be used for diagnosis?
A: HOMA-IR is a screening tool and should be used alongside other clinical assessments for diagnosis.

Q5: What units are required for the calculation?
A: Fasting insulin must be in μU/L and fasting glucose in mmol/L for the standard HOMA-IR calculation.