1. What Is The HOMA-IR Index?

The HOMA-IR (Homeostatic Model Assessment for Insulin Resistance) index is a method used to quantify insulin resistance. It calculates the balance between glucose and insulin levels in the fasting state, providing an indicator of how effectively the body uses insulin.

2. How Does The Calculator Work?

The calculator uses the HOMA-IR formula:

Where:

• Fasting Insulin — Measured in micro international units per liter (μU/L)
• Fasting Glucose — Measured in millimoles per liter (mmol/L)
• 22.5 — Normalization constant derived from healthy population data

Explanation: The equation evaluates the relationship between fasting insulin and glucose levels to estimate insulin resistance. Higher values indicate greater insulin resistance.

3. Importance Of HOMA-IR Calculation

Details: HOMA-IR is a valuable tool for assessing insulin resistance, which is associated with metabolic syndrome, type 2 diabetes, cardiovascular disease, and other health conditions. Early detection allows for preventive interventions.

4. Using The Calculator

Tips: Enter fasting insulin in μU/L and fasting glucose in mmol/L. Both values must be greater than zero. For accurate results, measurements should be taken after an overnight fast of 8-12 hours.

5. Frequently Asked Questions (FAQ)

Q1: What is a normal HOMA-IR value?
A: Typically, values below 2.0 are considered normal, though this may vary by population. Values above 2.5 often indicate insulin resistance.

Q2: How does HOMA-IR differ from other insulin resistance tests?
A: HOMA-IR is a simple calculation using fasting values, while other tests like the hyperinsulinemic-euglycemic clamp are more complex but considered the gold standard.

Q3: When should HOMA-IR testing be done?
A: It should be performed after an overnight fast, ideally in the morning. Avoid testing after recent illness, surgery, or changes in medication that affect glucose metabolism.

Q4: Are there limitations to the HOMA-IR calculation?
A: Yes, it may be less accurate in certain populations including those with type 1 diabetes, liver disease, or taking medications that affect insulin secretion.

Q5: Can HOMA-IR be used for diagnosis?
A: While it's a useful screening tool, diagnosis of insulin resistance should be confirmed with additional clinical assessment and possibly more definitive testing.