1. What is the HOMA-B Index?

The HOMA-B (Homeostatic Model Assessment for Beta Cell Function) index estimates pancreatic beta-cell function from fasting insulin and glucose levels. It provides an assessment of insulin secretion capacity and is commonly used in diabetes research and clinical practice.

2. How Does the Calculator Work?

The calculator uses the HOMA-B equation:

Where:

• Fasting Insulin — Measured in μU/L
• Fasting Glucose — Measured in mmol/L

Explanation: The equation calculates beta-cell function based on the relationship between fasting insulin and glucose levels, with 3.5 representing the theoretical glucose disposal rate.

3. Importance of HOMA-B Calculation

Details: HOMA-B assessment is crucial for evaluating insulin secretion capacity, diagnosing insulin resistance patterns, and monitoring beta-cell function in diabetes management and research studies.

4. Using the Calculator

Tips: Enter fasting insulin in μU/L and fasting glucose in mmol/L. Glucose must be greater than 3.5 mmol/L for valid calculation. Both values must be positive numbers.

5. Frequently Asked Questions (FAQ)

Q1: What are normal HOMA-B values?
A: Normal HOMA-B values typically range from 100% to 180%, though this can vary by population and laboratory methods.

Q2: When should insulin and glucose be measured?
A: Morning fasting samples are required after an 8-12 hour overnight fast for accurate results.

Q3: What does a low HOMA-B value indicate?
A: Low HOMA-B values suggest impaired beta-cell function and reduced insulin secretion capacity.

Q4: Are there limitations to this equation?
A: The equation assumes steady-state conditions and may be less accurate in non-fasting states or with rapidly changing glucose levels.

Q5: Can HOMA-B be used for diagnosis?
A: While useful for assessment, HOMA-B should be interpreted alongside other clinical findings and not used alone for diagnosis.