1. What is HOMA-IR?

HOMA-IR (Homeostatic Model Assessment for Insulin Resistance) is a method used to quantify insulin resistance and beta-cell function. It provides an estimate of insulin resistance based on fasting glucose and insulin levels.

2. How Does the Calculator Work?

The calculator uses the HOMA-IR formula:

Where:

• Fasting Insulin — Measured in μU/mL (microinternational units per milliliter)
• Fasting Glucose — Measured in mmol/L (millimoles per liter)
• 22.5 — Normalization constant

Explanation: The equation estimates insulin resistance by assessing the relationship between fasting insulin and glucose levels.

3. Importance of HOMA-IR Calculation

Details: HOMA-IR is widely used in clinical research and practice to identify insulin resistance, which is associated with type 2 diabetes, metabolic syndrome, and cardiovascular diseases.

4. Using the Calculator

Tips: Enter fasting insulin in μU/mL and fasting glucose in mmol/L. Both values must be greater than zero for accurate calculation.

5. Frequently Asked Questions (FAQ)

Q1: What are normal HOMA-IR values?
A: Normal HOMA-IR values are typically below 2.0. Values above 2.5 may indicate insulin resistance.

Q2: When should insulin and glucose be measured?
A: Both should be measured after an 8-12 hour overnight fast for accurate results.

Q3: Are there limitations to HOMA-IR?
A: HOMA-IR provides an estimate and may not be as accurate as more complex tests like hyperinsulinemic-euglycemic clamp.

Q4: Can HOMA-IR be used for diagnosis?
A: HOMA-IR is primarily used for research and screening purposes. Clinical diagnosis should be confirmed with additional tests.

Q5: What units are required for the calculation?
A: Insulin in μU/mL and glucose in mmol/L. Conversion may be needed if using different units.