1. What Is The HOMA-B Calculation?

The HOMA-B (Homeostatic Model Assessment for Beta Cell Function) estimates pancreatic beta-cell function from fasting insulin and glucose levels. It provides insight into insulin secretion capacity and is used in diabetes research and clinical assessment.

2. How Does The Calculator Work?

The calculator uses the HOMA-B equation:

Where:

• Fasting Insulin — Measured in μU/L
• Fasting Glucose — Measured in mmol/L

Explanation: The equation calculates beta-cell function based on the relationship between fasting insulin and glucose levels, with the constant 20 representing normal insulin sensitivity.

3. Importance Of HOMA-B Assessment

Details: HOMA-B assessment is important for evaluating insulin secretion capacity, identifying insulin resistance patterns, and monitoring beta-cell function in diabetic and pre-diabetic patients.

4. Using The Calculator

Tips: Enter fasting insulin in μU/L and fasting glucose in mmol/L. Both values must be positive, and glucose must be greater than 3.5 mmol/L for valid calculation.

5. Frequently Asked Questions (FAQ)

Q1: What are normal HOMA-B values?
A: Normal HOMA-B values typically range between 70-110% in healthy individuals, though this may vary based on population and laboratory standards.

Q2: When should HOMA-B be measured?
A: HOMA-B should be measured from fasting blood samples, ideally in the morning after an overnight fast of 8-12 hours.

Q3: What factors can affect HOMA-B results?
A: Recent food intake, medications affecting insulin/glucose, stress, illness, and physical activity can all influence HOMA-B results.

Q4: Are there limitations to the HOMA-B calculation?
A: The calculation assumes steady-state conditions and may not accurately reflect beta-cell function in all clinical situations, particularly in advanced diabetes.

Q5: Should HOMA-B be used alone for diagnosis?
A: No, HOMA-B should be used as part of a comprehensive assessment along with other clinical findings and laboratory tests for proper diagnosis and management.