1. What is the HOMA-IR Equation?

The HOMA-IR (Homeostatic Model Assessment for Insulin Resistance) is a method used to quantify insulin resistance and beta-cell function. It's calculated from fasting blood glucose and insulin levels.

2. How Does the Calculator Work?

The calculator uses the HOMA-IR equation:

Where:

• Fasting Insulin — Measured in μU/mL (microinternational units per milliliter)
• Fasting Glucose — Measured in mmol/L (millimoles per liter)
• 22.5 — Normalization constant

Explanation: The equation estimates insulin resistance based on the product of fasting insulin and glucose levels, normalized by a constant factor.

3. Importance of HOMA-IR Calculation

Details: HOMA-IR is a valuable tool for assessing insulin resistance, which is associated with type 2 diabetes, metabolic syndrome, and cardiovascular disease risk.

4. Using the Calculator

Tips: Enter fasting insulin in μU/mL and fasting glucose in mmol/L. Both values must be greater than zero for accurate calculation.

5. Frequently Asked Questions (FAQ)

Q1: What is a normal HOMA-IR value?
A: Typically, values below 1.0 indicate normal insulin sensitivity, while values above 2.0 suggest significant insulin resistance.

Q2: When should I test for HOMA-IR?
A: Testing should be done after an overnight fast of 8-12 hours for accurate results.

Q3: Are there limitations to HOMA-IR?
A: While useful for population studies, HOMA-IR may be less accurate for individuals with extremely high or low insulin levels.

Q4: Can HOMA-IR diagnose diabetes?
A: HOMA-IR assesses insulin resistance but should not be used alone to diagnose diabetes. It's best used alongside other clinical assessments.

Q5: How often should HOMA-IR be measured?
A: Frequency depends on individual risk factors, but typically it's measured annually for those at risk of metabolic disorders.