1. What is the HOMA-IR Index?

The HOMA-IR (Homeostatic Model Assessment of Insulin Resistance) is a method used to quantify insulin resistance and beta-cell function. It provides an estimate of insulin resistance from fasting blood glucose and insulin levels.

2. How Does the Calculator Work?

The calculator uses the HOMA-IR formula:

Where:

• Fasting Insulin — Measured in micro international units per milliliter (μU/mL)
• Fasting Glucose — Measured in millimoles per liter (mmol/L)
• 22.5 — Normalization constant derived from normal subjects

Explanation: The equation estimates insulin resistance by assessing the relationship between fasting glucose and insulin levels.

3. Importance of HOMA-IR Calculation

Details: HOMA-IR is widely used in clinical research and practice to identify insulin resistance, which is associated with type 2 diabetes, metabolic syndrome, and cardiovascular diseases.

4. Using the Calculator

Tips: Enter fasting insulin in μU/mL and fasting glucose in mmol/L. Both values must be greater than zero for accurate calculation.

5. Frequently Asked Questions (FAQ)

Q1: What is a normal HOMA-IR value?
A: Typically, values below 2.0 are considered normal, though this may vary by population and laboratory standards.

Q2: How should the blood samples be collected?
A: Blood samples should be collected after an overnight fast (8-12 hours) for accurate results.

Q3: Are there limitations to HOMA-IR?
A: HOMA-IR provides an estimate rather than a direct measurement and may be less accurate in certain conditions like advanced diabetes or liver disease.

Q4: Can HOMA-IR be used for diagnosis?
A: While useful for screening and research, it should not be used alone for clinical diagnosis without additional tests and clinical evaluation.

Q5: How often should HOMA-IR be measured?
A: Frequency depends on individual risk factors and clinical context, typically monitored during metabolic assessments.