1. What is the HOMA-IR Index?

The HOMA-IR (Homeostatic Model Assessment of Insulin Resistance) is a method used to quantify insulin resistance and beta-cell function. It provides a simple and reliable assessment of insulin sensitivity from fasting glucose and insulin measurements.

2. How Does the Calculator Work?

The calculator uses the HOMA-IR equation:

Where:

• Fasting Insulin — Measured in micro international units per milliliter (μU/mL)
• Fasting Glucose — Measured in millimoles per liter (mmol/L)
• 22.5 — Normalization constant

Explanation: The equation estimates insulin resistance based on the product of fasting insulin and glucose levels, normalized by the constant 22.5 which represents normal insulin sensitivity.

3. Importance of HOMA-IR Calculation

Details: HOMA-IR is widely used in clinical research and practice to assess insulin resistance, which is a key factor in metabolic syndrome, type 2 diabetes, and cardiovascular diseases.

4. Using the Calculator

Tips: Enter fasting insulin in μU/mL and fasting glucose in mmol/L. Both values must be greater than zero for accurate calculation.

5. Frequently Asked Questions (FAQ)

Q1: What is a normal HOMA-IR value?
A: Typically, values below 2.5 are considered normal, though this may vary by population and laboratory standards.

Q2: When should I measure insulin and glucose levels?
A: Measurements should be taken after an 8-12 hour overnight fast for accurate results.

Q3: Can HOMA-IR be used for diagnosis?
A: While HOMA-IR is a useful screening tool, it should not be used alone for diagnosis. Clinical evaluation and other tests are necessary.

Q4: Are there limitations to HOMA-IR?
A: Yes, it may be less accurate in certain populations such as those with type 1 diabetes or extreme insulin levels.

Q5: How often should HOMA-IR be measured?
A: Frequency depends on individual risk factors and clinical context. Consult with your healthcare provider for personalized advice.