1. What is HOMA-IR?

HOMA-IR (Homeostatic Model Assessment for Insulin Resistance) is a method used to quantify insulin resistance and beta-cell function. It provides an estimate of insulin resistance from fasting blood glucose and insulin levels.

2. How Does the Calculator Work?

The calculator uses the HOMA-IR formula:

Where:

• Fasting Insulin — Measured in micro international units per liter (μU/L)
• Fasting Glucose — Measured in millimoles per liter (mmol/L)
• 22.5 — Normalization constant

Explanation: The formula calculates insulin resistance based on the product of fasting insulin and glucose levels, normalized by the constant 22.5.

3. Importance of HOMA-IR Calculation

Details: HOMA-IR is widely used in clinical research and practice to assess insulin resistance, which is associated with type 2 diabetes, metabolic syndrome, and cardiovascular diseases.

4. Using the Calculator

Tips: Enter fasting insulin in μU/L and fasting glucose in mmol/L. Both values must be valid (greater than 0). Morning fasting samples provide the most accurate results.

5. Frequently Asked Questions (FAQ)

Q1: What is a normal HOMA-IR value?
A: Typically, values below 2.0 are considered normal insulin sensitivity, while values above 2.0 may indicate insulin resistance.

Q2: Can HOMA-IR be used for diagnosis?
A: While HOMA-IR is a useful screening tool, it should not be used alone for diagnosis. Clinical evaluation and other tests are necessary for definitive diagnosis.

Q3: Are there limitations to HOMA-IR?
A: Yes, HOMA-IR may be less accurate in certain populations, such as those with type 1 diabetes, pancreatic disorders, or extreme obesity.

Q4: How often should HOMA-IR be measured?
A: Frequency depends on individual risk factors and clinical context. It's typically measured during routine metabolic assessments.

Q5: Can medications affect HOMA-IR results?
A: Yes, medications that affect insulin secretion or sensitivity (like metformin or insulin) can influence HOMA-IR values.