1. What is HOMA-IR?

HOMA-IR (Homeostatic Model Assessment for Insulin Resistance) is a method used to quantify insulin resistance and beta-cell function. It provides an estimate of insulin sensitivity based on fasting glucose and insulin levels.

2. How Does the Calculator Work?

The calculator uses the HOMA-IR formula:

Where:

• Fasting Insulin — Measured in microinternational units per milliliter (μU/mL)
• Fasting Glucose — Measured in millimoles per liter (mmol/L)
• 22.5 — Normalization constant derived from normal subjects

Explanation: The formula calculates insulin resistance by assessing the relationship between fasting insulin and glucose levels.

3. Importance of HOMA-IR Calculation

Details: HOMA-IR is widely used in clinical research and practice to identify insulin resistance, which is associated with type 2 diabetes, metabolic syndrome, and cardiovascular diseases.

4. Using the Calculator

Tips: Enter fasting insulin in μU/L and fasting glucose in mmol/L. Both values must be positive numbers obtained from fasting blood tests.

5. Frequently Asked Questions (FAQ)

Q1: What is a normal HOMA-IR value?
A: Typically, values below 2.0 are considered normal, while values above 2.5-3.0 indicate insulin resistance.

Q2: When should HOMA-IR be measured?
A: After an overnight fast of 8-12 hours, ideally in the morning before any food or caloric intake.

Q3: Are there limitations to HOMA-IR?
A: Yes, it's less accurate in people with impaired beta-cell function and may not reflect postprandial insulin dynamics.

Q4: Can HOMA-IR be used for diagnosis?
A: While useful for screening and research, it should not be used alone for clinical diagnosis without additional tests.

Q5: How often should HOMA-IR be tested?
A: Frequency depends on individual risk factors and clinical context, typically annually for at-risk individuals.