1. What is the HOMA-B Equation?

The HOMA-B (Homeostatic Model Assessment for Beta Cell Function) equation estimates pancreatic beta cell function from fasting insulin and glucose levels. It provides an assessment of insulin secretion capacity and is commonly used in diabetes research and clinical practice.

2. How Does the Calculator Work?

The calculator uses the HOMA-B equation:

Where:

• Fasting Insulin — Measured in μU/L (microinternational units per liter)
• Fasting Glucose — Measured in mmol/L (millimoles per liter)

Explanation: The equation calculates beta cell function as a percentage of normal, with 100% representing normal function. Higher values indicate better beta cell function.

3. Importance of HOMA-B Calculation

Details: HOMA-B assessment is crucial for evaluating insulin secretion capacity, diagnosing insulin resistance patterns, monitoring diabetes progression, and assessing treatment effectiveness in diabetic patients.

4. Using the Calculator

Tips: Enter fasting insulin in μU/L and fasting glucose in mmol/L. Both values must be valid positive numbers, and glucose cannot be exactly 3.5 mmol/L (to avoid division by zero).

5. Frequently Asked Questions (FAQ)

Q1: What is a normal HOMA-B value?
A: Normal HOMA-B values typically range from 80% to 120%, with 100% representing normal beta cell function.

Q2: How does HOMA-B relate to diabetes?
A: Lower HOMA-B values indicate reduced beta cell function, which is characteristic of type 2 diabetes progression.

Q3: When should insulin and glucose be measured?
A: Both should be measured after an overnight fast (8-12 hours) for accurate results. Avoid testing after meals or strenuous exercise.

Q4: Are there limitations to the HOMA-B equation?
A: The equation assumes steady-state conditions and may be less accurate in extreme insulin resistance or rapidly changing metabolic states.

Q5: Can HOMA-B be used for type 1 diabetes?
A: HOMA-B is primarily used for type 2 diabetes assessment. In type 1 diabetes, beta cell function is typically severely impaired.