1. What is the HOMA2 Calculator?

The HOMA2 (Homeostatic Model Assessment 2) calculator is an updated computational model that estimates insulin resistance (HOMA2-IR) and beta-cell function (HOMA2-%B) from fasting insulin and glucose levels. It provides more accurate results than the original HOMA1 formula.

2. How Does the Calculator Work?

The HOMA2 model uses a complex mathematical model rather than a simple formula. It requires:

• Fasting Insulin (μU/mL or pmol/L)
• Fasting Glucose (mg/dL or mmol/L)

Explanation: The model uses iterative computational methods to solve a set of differential equations that describe the glucose-insulin feedback system, providing more accurate estimates of insulin resistance and beta-cell function.

3. Importance of HOMA2-IR Calculation

Details: HOMA2-IR is crucial for assessing insulin resistance, which is a key factor in metabolic syndrome, type 2 diabetes, and cardiovascular disease risk assessment.

4. Using the Calculator

Tips: Enter fasting insulin and glucose values with appropriate units. For accurate results, measurements should be taken after an overnight fast of 8-12 hours.

5. Frequently Asked Questions (FAQ)

Q1: What is the difference between HOMA1 and HOMA2?
A: HOMA2 uses a more complex computational model that provides more accurate results, especially at extreme values, and includes corrections for variations in hepatic and peripheral glucose resistance.

Q2: What are normal HOMA2-IR values?
A: Typically, HOMA2-IR values below 1.0 indicate normal insulin sensitivity, while values above 1.8-2.0 suggest insulin resistance.

Q3: When should insulin and glucose be measured?
A: Morning fasting samples after an overnight fast of 8-12 hours provide the most accurate results for HOMA2 calculation.

Q4: Are there limitations to the HOMA2 model?
A: The model assumes steady-state conditions and may be less accurate in certain populations such as pregnant women, children, or those with type 1 diabetes.

Q5: Where can I find the official HOMA2 calculator?
A: The official HOMA2 calculator is available from the University of Oxford Diabetes Trial Unit and requires specific software for accurate computation.