1. What is HOMA-IR?

HOMA-IR (Homeostatic Model Assessment for Insulin Resistance) is a method used to quantify insulin resistance and beta-cell function. It's calculated from fasting insulin and glucose levels.

2. How Does the Calculator Work?

The calculator uses the HOMA-IR formula:

Where:

• Fasting Insulin — Measured in μU/L (microinternational units per liter)
• Fasting Glucose — Measured in mmol/L (millimoles per liter)
• 22.5 — Constant factor for normalization

Explanation: The formula estimates insulin resistance based on the product of fasting insulin and glucose levels, normalized by the constant 22.5.

3. Importance of HOMA-IR Calculation

Details: HOMA-IR is widely used in clinical research and practice to assess insulin resistance, which is associated with type 2 diabetes, metabolic syndrome, and cardiovascular diseases.

4. Using the Calculator

Tips: Enter fasting insulin in μU/L and fasting glucose in mmol/L. Both values must be positive numbers obtained from fasting blood tests.

5. Frequently Asked Questions (FAQ)

Q1: What is a normal HOMA-IR value?
A: Typically, values below 2.0 are considered normal, while values above 2.5-3.0 may indicate insulin resistance.

Q2: When should I measure insulin and glucose levels?
A: Both measurements should be taken after an 8-12 hour overnight fast for accurate results.

Q3: Are there limitations to HOMA-IR?
A: Yes, it's less accurate in people with impaired beta-cell function and may not reflect postprandial insulin dynamics.

Q4: Can HOMA-IR be used for diagnosis?
A: It's primarily used as a screening tool and research measure rather than a definitive diagnostic test.

Q5: How often should HOMA-IR be measured?
A: Frequency depends on individual risk factors and clinical context, typically as part of metabolic assessments.