1. What is HOMA-IR?

HOMA-IR (Homeostatic Model Assessment for Insulin Resistance) is a method used to quantify insulin resistance and beta-cell function from fasting blood glucose and insulin levels. It provides an estimate of insulin sensitivity.

2. How Does the Calculator Work?

The calculator uses the HOMA-IR formula:

Where:

• Fasting Insulin — Measured in micro international units per milliliter (μU/mL)
• Fasting Glucose — Measured in millimoles per liter (mmol/L)
• 22.5 — Normalization constant

Explanation: The equation estimates insulin resistance based on the product of fasting insulin and glucose levels, normalized by a constant factor.

3. Importance of HOMA-IR Calculation

Details: HOMA-IR is crucial for assessing insulin resistance, which is associated with metabolic syndrome, type 2 diabetes, cardiovascular disease, and other health conditions.

4. Using the Calculator

Tips: Enter fasting insulin in μU/L and fasting glucose in mmol/L. Both values must be greater than zero for accurate calculation.

5. Frequently Asked Questions (FAQ)

Q1: What are normal HOMA-IR values?
A: Normal HOMA-IR values are typically below 2.0. Values above 2.0 may indicate insulin resistance.

Q2: When should insulin and glucose be measured?
A: Both should be measured after an 8-12 hour fast for accurate results.

Q3: Are there limitations to HOMA-IR?
A: HOMA-IR is an estimate and may not be accurate in all populations, particularly those with extreme insulin levels or advanced diabetes.

Q4: Can HOMA-IR be used for diagnosis?
A: HOMA-IR is a screening tool and should be used in conjunction with other clinical assessments for diagnosis.

Q5: What factors can affect HOMA-IR results?
A: Recent food intake, medications, stress, and physical activity can all influence insulin and glucose levels.