Como Calcular Índice De HOMA Beta

HOMA-B Formula:

\[ HOMA-B = \frac{20 \times \text{Fasting Insulin}}{\text{Fasting Glucose} - 3.5} \]

HOMA-B Index:

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1. What is HOMA-B Index?

The HOMA-B (Homeostatic Model Assessment for Beta Cell Function) index estimates pancreatic beta-cell function from fasting glucose and insulin levels. It provides an assessment of insulin secretion capacity and is used in diabetes research and clinical practice.

2. How Does the Calculator Work?

The calculator uses the HOMA-B formula:

\[ HOMA-B = \frac{20 \times \text{Fasting Insulin}}{\text{Fasting Glucose} - 3.5} \]

Where:

Fasting Insulin — Measured in μU/L
Fasting Glucose — Measured in mmol/L

Explanation: The formula calculates beta-cell function based on the mathematical model of homeostasis between glucose and insulin levels in the fasting state.

3. Importance of HOMA-B Calculation

Details: HOMA-B assessment is crucial for evaluating insulin secretion capacity, monitoring beta-cell function in diabetes progression, and assessing treatment response in diabetic patients.

4. Using the Calculator

Tips: Enter fasting insulin in μU/L and fasting glucose in mmol/L. Both values must be valid (greater than 0). Glucose must be greater than 3.5 mmol/L for the calculation to be valid.

5. Frequently Asked Questions (FAQ)

Q1: What are normal HOMA-B values?
A: Normal HOMA-B values typically range from 80-120% in healthy individuals, though this can vary based on age, BMI, and other factors.

Q2: When should HOMA-B be measured?
A: HOMA-B should be measured from fasting blood samples collected after an overnight fast of 8-12 hours for accurate results.

Q3: What does a low HOMA-B value indicate?
A: A low HOMA-B value indicates impaired beta-cell function and reduced insulin secretion capacity, which is characteristic of type 2 diabetes.

Q4: Are there limitations to the HOMA-B model?
A: The HOMA model assumes certain physiological conditions and may be less accurate in extreme metabolic states, pregnancy, or in patients with liver disease.

Q5: How does HOMA-B differ from HOMA-IR?
A: HOMA-B assesses beta-cell function (insulin secretion), while HOMA-IR assesses insulin resistance. Both are calculated from fasting glucose and insulin levels but serve different diagnostic purposes.