1. What is the HOMA-IR Formula?

The HOMA-IR (Homeostatic Model Assessment for Insulin Resistance) is a method used to quantify insulin resistance and beta-cell function. It provides a simple and reliable assessment of insulin resistance from fasting glucose and insulin levels.

2. How Does the Calculator Work?

The calculator uses the HOMA-IR equation:

Where:

• Fasting Insulin — Measured in μU/mL (microinternational units per milliliter)
• Fasting Glucose — Measured in mmol/L (millimoles per liter)
• 22.5 — Normalization constant

Explanation: The equation estimates insulin resistance by calculating the product of fasting insulin and glucose levels, normalized by the constant 22.5 which represents normal insulin sensitivity.

3. Importance of HOMA-IR Calculation

Details: HOMA-IR is widely used in clinical research and practice to assess insulin resistance, which is a key factor in metabolic syndrome, type 2 diabetes, and cardiovascular diseases.

4. Using the Calculator

Tips: Enter fasting insulin in μU/L and fasting glucose in mmol/L. Both values must be greater than zero for accurate calculation.

5. Frequently Asked Questions (FAQ)

Q1: What are normal HOMA-IR values?
A: Typically, values below 2.0 indicate normal insulin sensitivity, while values above 2.0 suggest insulin resistance.

Q2: When should insulin and glucose be measured?
A: Both should be measured after an 8-12 hour overnight fast for accurate results.

Q3: Are there limitations to HOMA-IR?
A: While useful for population studies, it may be less accurate for individuals with extreme values or certain medical conditions.

Q4: Can HOMA-IR be used for diagnosis?
A: It's a screening tool rather than a diagnostic test. Clinical correlation and additional tests are usually needed for diagnosis.

Q5: How often should HOMA-IR be calculated?
A: Frequency depends on clinical context, but it's commonly used for monitoring treatment response in metabolic disorders.