1. What is HOMA-IR?

HOMA-IR (Homeostatic Model Assessment for Insulin Resistance) is a method used to quantify insulin resistance and beta-cell function. It's calculated from fasting insulin and glucose levels.

2. How Does the Calculator Work?

The calculator uses the HOMA-IR formula:

Where:

• Fasting Insulin — Measured in micro international units per milliliter (μU/mL)
• Fasting Glucose — Measured in millimoles per liter (mmol/L)
• 22.5 — Normalization constant

Explanation: The equation estimates insulin resistance based on the product of fasting insulin and glucose levels, normalized by a constant factor.

3. Importance of HOMA-IR Calculation

Details: HOMA-IR is widely used in research and clinical practice to assess insulin resistance, which is associated with type 2 diabetes, metabolic syndrome, and cardiovascular diseases.

4. Using the Calculator

Tips: Enter fasting insulin in μU/L and fasting glucose in mmol/L. Both values must be greater than zero for accurate calculation.

5. Frequently Asked Questions (FAQ)

Q1: What are normal HOMA-IR values?
A: Normal HOMA-IR values are typically below 2.0. Values above 2.5 may indicate insulin resistance, and above 5.0 suggest significant insulin resistance.

Q2: When should insulin and glucose be measured?
A: Both should be measured after an 8-12 hour overnight fast for accurate results.

Q3: Are there limitations to HOMA-IR?
A: HOMA-IR provides an estimate rather than a direct measurement of insulin resistance and may be less accurate in certain populations like pregnant women or those with liver disease.

Q4: Can HOMA-IR be used for diagnosis?
A: While useful for screening and research, HOMA-IR should not be used alone for clinical diagnosis without additional tests and clinical evaluation.

Q5: How often should HOMA-IR be measured?
A: Frequency depends on individual risk factors and clinical context. Typically monitored annually for at-risk individuals or as part of metabolic health assessments.