1. What is the HOMA-IR Equation?

The HOMA-IR (Homeostatic Model Assessment of Insulin Resistance) is a method used to quantify insulin resistance and beta-cell function. It provides an estimate of insulin resistance from fasting blood glucose and insulin levels.

2. How Does the Calculator Work?

The calculator uses the HOMA-IR equation:

Where:

• Fasting Insulin — Measured in micro international units per milliliter (μU/mL)
• Fasting Glucose — Measured in millimoles per liter (mmol/L)
• 22.5 — Normalization constant

Explanation: The equation estimates insulin resistance by assessing the relationship between fasting glucose and insulin levels.

3. Importance of HOMA-IR Calculation

Details: HOMA-IR is widely used in clinical research and practice to assess insulin resistance, which is a key factor in metabolic syndrome, type 2 diabetes, and cardiovascular diseases.

4. Using the Calculator

Tips: Enter fasting insulin in μU/L and fasting glucose in mmol/L. Both values must be greater than zero for accurate calculation.

5. Frequently Asked Questions (FAQ)

Q1: What is a normal HOMA-IR value?
A: Typically, HOMA-IR values below 2.0 are considered normal, while values above 2.9 may indicate insulin resistance.

Q2: When should blood samples be taken for HOMA-IR?
A: Blood samples should be collected after an 8-12 hour overnight fast for accurate results.

Q3: Are there limitations to the HOMA-IR model?
A: Yes, HOMA-IR provides an estimate rather than a direct measurement and may be less accurate in certain populations or extreme conditions.

Q4: Can HOMA-IR be used for diagnosis?
A: HOMA-IR is a screening tool and should be used in conjunction with other clinical assessments for diagnosis.

Q5: What units are required for the calculation?
A: Insulin in μU/L and glucose in mmol/L. Conversion may be needed if using different units.