1. What is the Oxford HOMA2 Calculator?

The Oxford HOMA2 Calculator is a computational model developed by Oxford University for assessing insulin resistance (HOMA2-IR) and beta-cell function (HOMA2-%B) using fasting insulin and glucose measurements.

2. How Does the Calculator Work?

The calculator uses a sophisticated computational model that requires specialized software from Oxford University. It provides more accurate results than the original HOMA model by accounting for variations in hepatic and peripheral glucose metabolism.

Input Parameters:

• Fasting Insulin (μU/mL or pmol/L)
• Fasting Glucose (mg/dL or mmol/L)

Output Values:

• HOMA2-IR - Insulin resistance index
• HOMA2-%B - Beta-cell function percentage

3. Importance of HOMA2 Assessment

Details: The HOMA2 model provides valuable insights into insulin resistance and pancreatic beta-cell function, which are crucial for diagnosing and managing type 2 diabetes, metabolic syndrome, and related conditions.

4. Using the Calculator

Tips: Enter fasting insulin and glucose values with appropriate units. For accurate results, measurements should be taken after an overnight fast of 8-12 hours. All values must be valid and greater than zero.

5. Frequently Asked Questions (FAQ)

Q1: Why use HOMA2 instead of the original HOMA model?
A: HOMA2 provides more accurate estimates by using a computational model that better reflects human physiology and accounts for variations in glucose metabolism.

Q2: What are normal HOMA2 values?
A: Normal HOMA2-IR is typically around 1.0. Values above 1.8-2.0 may indicate insulin resistance. HOMA2-%B normally ranges from 70-130%.

Q3: When should insulin and glucose be measured?
A: Morning fasting samples after 8-12 hours of overnight fasting provide the most reliable results for HOMA2 calculations.

Q4: Are there limitations to the HOMA2 model?
A: The model may be less accurate in certain populations, including those with type 1 diabetes, liver disease, or extreme insulin levels.

Q5: Where can I find the official Oxford HOMA2 software?
A: The official HOMA2 software is available from the University of Oxford Diabetes Trials Unit for research and clinical use.