Calculadora De HOMA IR E Beta

HOMA Equations:

\[ \text{HOMA-IR} = \frac{\text{Fasting Insulin} \times \text{Fasting Glucose}}{22.5} \] \[ \text{HOMA-B} = \frac{20 \times \text{Fasting Insulin}}{\text{Fasting Glucose} - 3.5} \]

HOMA-IR:

HOMA-B:

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1. What is HOMA-IR and HOMA-B?

The HOMA (Homeostatic Model Assessment) equations are mathematical models used to estimate insulin resistance (HOMA-IR) and beta cell function (HOMA-B) from fasting insulin and glucose measurements. These are important tools in diabetes research and clinical assessment.

2. How Does the Calculator Work?

The calculator uses the HOMA equations:

\[ \text{HOMA-IR} = \frac{\text{Fasting Insulin} \times \text{Fasting Glucose}}{22.5} \] \[ \text{HOMA-B} = \frac{20 \times \text{Fasting Insulin}}{\text{Fasting Glucose} - 3.5} \]

Where:

Fasting Insulin — Measured in μU/L (microinternational units per liter)
Fasting Glucose — Measured in mmol/L (millimoles per liter)
22.5 and 20 — Constants derived from normal physiological values

Explanation: HOMA-IR quantifies insulin resistance, while HOMA-B estimates pancreatic beta cell function based on fasting insulin and glucose levels.

3. Importance of HOMA Calculations

Details: These calculations help assess metabolic health, identify insulin resistance patterns, evaluate beta cell function in diabetes management, and monitor treatment effectiveness in metabolic disorders.

4. Using the Calculator

Tips: Enter fasting insulin in μU/L and fasting glucose in mmol/L. Both values must be positive. For HOMA-B calculation, glucose must be greater than 3.5 mmol/L.

5. Frequently Asked Questions (FAQ)

Q1: What are normal HOMA-IR values?
A: Typically, HOMA-IR values below 2.0 are considered normal, though this may vary by population and laboratory standards.

Q2: What do HOMA-B values indicate?
A: Higher HOMA-B values indicate better beta cell function, while lower values suggest impaired insulin secretion capacity.

Q3: When should these tests be performed?
A: After an overnight fast (8-12 hours), avoiding strenuous exercise and medications that affect glucose metabolism before testing.

Q4: Are there limitations to HOMA calculations?
A: Yes, they provide estimates rather than direct measurements and may be less accurate in certain conditions like advanced diabetes or extreme insulin levels.

Q5: Can HOMA replace glucose tolerance tests?
A: While useful for screening, HOMA calculations cannot replace comprehensive glucose tolerance tests for definitive diagnosis of glucose metabolism disorders.